USA men’s national squad players will be back in domestic cricket action after a successful ICC Men’s T20 World Cup Americas qualifiers campaign in Antigua, as USA Cricket will be hosting the 50-overs National Championships at the MLC National Cricket Center at Prairie View Cricket Complex in Texas from November 15th – 19th, 2021. There will be live broadcast of four (4) games from the competition including the Final on USA Cricket’s YouTube channel, in collaboration with CricClubs.
The eight (8) participating teams (team each from East Zone, Mid-Atlantic Zone, South Zone, Midwest Zone, South West Zone, West Zone Blues, West Zone Reds and USA Cricket U19) have been divided into two groups of four (4) teams each and will play each other in a single round-robin group stage format, following which the two group winners will advance to the National Championships Final on November 19th, while the two 2nd place sides in the groups will play in the 3rd/4th play-off game, and the two 3rd place sides playing off for 5th/6th position play-off game and the bottom two sides in the group competing in the 7th/8th position play-off game.
| Date | Match#1 (Live Broadcast) | Match#2 | Match#3 | Match#4 |
| 15 November 2021 | East v Midwest | West Blue v South | West Red v South West | Mid-Atlantic v USA U19 |
| 16 November 2021 | South v Mid-Atlantic | Midwest v West Red | USA U19 v West Blue | South West v East |
| 18 November 2021 | West Blue v Mid-Atlantic | Midwest v South West | East v West Red | South v USA U19 |
| 19 November 2021 | Final (1st Group A vs 1st Group B) | 3rd v 4th Play-off | 5th v 6th Play-off | 7th v 8th Play-off |
